Does this search engine work with frames?
Yes. The frames and framesets are followed by spider and the pages get indexed.

How do I have the search results appear in the frame of my choice?
When you insert the search form to your web site, use an attribute TARGET in the HTML Tag <FORM> For example, if your central frame is called _main, use:

<FORM TARGET="_main" ACTION=...>

Can I "target" the page links in the search results?
Not in CGI interface. You will have to use XML or SOAP interface which allow for full customization of search results.

How do I ensure that a page has the correct frameset around it?
For sites with single a frameset, the technique is to display the search results in your "main" (or "content") frame and ensure that only "main" pages get indexed. For sites with multiple framesets, the technique is to use some javascript on every page, which ensures the correct frameset is loaded around the page.

Can I prevent the "Frame in a Frame" look?
Yes. If you configured your search form to show the search results in a frame, you need to ensure that only pages that belong in that same frame are indexed.